Observational studies suggest that conventional right ventricular apical pacing may have a deleterious effect on left ventricular function. In this study, we examined whether biventricular pacing is superior to right ventricular apical pacing in preventing deterioration of left ventricular systolic function and cardiac remodeling in patients with bradycardia and a normal ejection fraction.
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Yu, C.-M., Chan, J. Y.-S., Zhang, Q., Omar, R., Yip, G. W.-K., Hussin, A., … Fung, J. W.-H. (2009). Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction. New England Journal of Medicine, 361(22), 2123–2134. https://doi.org/10.1056/nejmoa0907555