Genomic Sequencing Procedure Microcosting Analysis and Health Economic Cost-Impact Analysis

  • Sabatini L
  • Mathews C
  • Ptak D
  • et al.
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Abstract

The ASCP designates this journal-based CME activity ("JMD 2016 CME Program in Molecular Diagnostics") for a maximum of 36 AMA PRA Category 1 Credit(s)ä. Physicians should only claim credit commensurate with the extent of their participation in the activity. CME Disclosures: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. The increasing use of advanced nucleic acid sequencing technologies for clinical diagnostics and therapeutics has made vital understanding the costs of performing these procedures and their value to patients, providers, and payers. The Association for Molecular Pathology invested in a cost and value analysis of specific genomic sequencing procedures (GSPs) newly coded by the American Medical Association Current Procedural Terminology Editorial Panel. Cost data and work effort, including the development and use of data analysis pipelines, were gathered from representative laboratories currently performing these GSPs. Results were aggregated to generate representative cost ranges given the complexity and variability of performing the tests. Cost-impact models for three clinical scenarios were generated with assistance from key opinion leaders: impact of using a targeted gene panel in optimizing care for patients with advanced nonesmall-cell lung cancer, use of a targeted gene panel in the diagnosis and management of patients with sensorineural hearing loss, and exome sequencing in the diagnosis and management of children with neurodevelopmental disorders of unknown genetic etiology. Each model demonstrated value by either reducing health care costs or identifying appropriate care pathways. The templates generated will aid laboratories in assessing

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APA

Sabatini, L. M., Mathews, C., Ptak, D., Doshi, S., Tynan, K., Hegde, M. R., … Bossler, A. D. (2016). Genomic Sequencing Procedure Microcosting Analysis and Health Economic Cost-Impact Analysis. The Journal of Molecular Diagnostics, 18(3), 319–328. https://doi.org/10.1016/j.jmoldx.2015.11.010

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