Estimation and comparison of serum and salivary IgA levels in controlled, uncontrolled diabetics and normal individuals

Abstract

Diabetes mellitus is a disease of absolute or relative insulin deficiency characterized by insufficient secretion of insulin by the pancreatic beta cells. In diabetes there is proliferation and swelling of endothelial cells, frequently obliterating the vessel lumen which leads to reduced blood flow and decrease in oxygen diffusion leads to good environment for growth of microorganism. The present study was carried out with the aim of getting information on humoral immune status of individuals having diabetes by measuring the serum and salivary IgA levels. With intense review of literature and observation we concluded with there was statistically significant increase in the salivary IgA level in controlled and uncontrolled diabetics compared to normal individuals and serum IgA level was higher in controlled and uncontrolled diabetics compared to normal individuals.