Review of synthetic strategies in the development of oxadiazine scaffolds

Abstract

Heterocycles containing both oxygen and nitrogen are in a tremendous demand for their immense biological activities. Oxadiazines are the scaffolds shown pleasing activities like antibacterial, antifungal, anthelmintic, anti-inflammatory, locomotor, anticonvulsive, antiviral, antitumor, agricultural, insecticidal, nematocidal, miticidal, neurogenerative disorders like Alzheimer disease, blood disorders like anemia and plant regulation. Multiple syntheses of oxadiazine scaffolds like 1,2,4-oxadiazines, 1,2,5-oxadiazines, 1,3,4-oxadiazines, 1,3,5-oxadiazines have been summarized in the review. Several research chemists are making attempts to discover and introduce the new scaffolds for various diseases ailments in the present scenario. Here we made an attempt to introduce the scaffolds of substituted oxadiazines because a lesser amount of research was carried out on these nuclei.