New technologies allow for genome-scale measurement of DNA methylation. In an effort to increase the clinical utility of DNA methylation as a biomarker, we have adapted a commercial bisulfite epigenotyping assay for genome-wide methylation profiling in archival formalin-fixed paraffin-embedded pathology specimens. This chapter takes the reader step by step through a biomarker discovery experiment to identify phenotype-correlated DNA methylation signatures in routine pathology specimens. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Killian, J. K., Walker, R. L., Bilke, S., Chen, Y., Davis, S., Cornelison, R., … Meltzer, P. S. (2012). Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples. Methods in Molecular Biology, 823, 107–118. https://doi.org/10.1007/978-1-60327-216-2_8
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