Low heart rate variability relates to the progression of gastric cancer

Abstract

Background: Gastric cancer (GC) is one of the most common malignant gastrointestinal tumors with the high morbidity and mortality, affecting the quality of human life. This study aimed to identify the role of heart rate variability (HRV) in patients with GC. Methods: From January 2010 to June 2014, 383 consecutive patients diagnosed with GC were enrolled in this study. Clinical and pathological information from each patient were retrospectively recorded. HRV, including standard deviation of normal-to-normal RR intervals (SDNN) and root mean square of successive differences (RMSSD), were measured by electrocardiography. Results: The results showed that the SDNN and RMSSD in GC patients were 19.02±13.58 ms and 21.64±17.57 ms, respectively. HRV decreased with advanced clinical stage (P<0.0001). HRV correlated with tumor size, tumor infiltration, lymph node metastasis and distant metastasis (P<0.001); however, no correlation with tumor site and metastasis severity was found (P>0.05). C-reactive protein (CRP) was higher in the low HRV group than that in high HRV group (P=0.008). Conclusions: GC patients showed a lower HRV that was correlated with tumor stage. HRV decreased with tumor progression, which may be related to a mechanism involving vagal nerve excitement inhibiting the inflammatory reaction.