Studies with 6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl-acetonitrile: Novel syntheses of 1-azolyl- And pyridoisoquinolines

Abstract

The reaction of 3,4-dihydroisoquinolin-1-yl-acetonitrile with DMFDMA afforded the enaminonitrile 5. Compound 5 was reacted with 2-aminobenzimidazole to yield 4-amino-3-(dihydroisoquinolin-1-yl)-benzo[4,5]imidazo[1,2-a]pyrirnidine (11) and with acetonitrile derivatives to afford pyrido[2,1-a]isoquinolines (15a - g). © 2007 Verlag der Zeitschrift für Naturforschung.