Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design

4Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Metformin hydrochloride (HCl) microspheres and nanoparticles were formulated to enhance bioavailability and minimize side effects through sustained action and optimized drug-release characteristics. Initially, the same formulation design with different ratios of metformin HCl and Eudragit RSPO was used to formulate four batches of microspheres and nanoparticles using solvent evaporation and nanoprecipitation methods, respectively. Methods: The produced formulations were evaluated based on particle size and shape (particle size distribution (PSD), scanning electron microscope (SEM)), incompatibility (differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR)), drug release pattern, permeation behavior, in vivo hypoglycemic effects, and in vitro anticancer potential. Results: Compatibility studies concluded that there was minimal interaction between metformin HCl and the polymer, whereas SEM images revealed smoother, more spherical nanoparticles than microspheres. Drug release from the formulations was primarily controlled by the non-Fickian diffusion process, except for A1 and A4 by Fickian, and B3 by Super case II. Korsmeyer-Peppas was the best-fit model for the maximum formulations. The best formulations of microspheres and nanoparticles, based on greater drug release, drug entrapment, and compatibility characteristics, were attributed to the study of drug permeation by non-everted intestinal sacs, in vivo anti-hyperglycemic activity, and in vitro anticancer activity. Conclusion: This study suggests that the proposed metformin HCl formulation can dramatically reduce hyperglycemic conditions and may also have anticancer potential.

References Powered by Scopus

Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030

12628Citations
N/AReaders
Get full text

Mechanisms of solute release from porous hydrophilic polymers

4641Citations
N/AReaders
Get full text

A simple equation for description of solute release II. Fickian and anomalous release from swellable devices

3731Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Advances in metformin-delivery systems for diabetes and obesity management

1Citations
N/AReaders
Get full text

Efficacy of pegylated Graphene oxide quantum dots as a nanoconjugate sustained release metformin delivery system in in vitro insulin resistance model

0Citations
N/AReaders
Get full text

Improved synthesis of metformin hydrochloride-sodium alginate (MH-NaALG) microspheres using ultrasonic spray drying

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kotha, A. A., Ahmad, S. U., Dewan, I., Rahman, F. I., Mohamed, I. N., Reza, M. S., & Bhuiyan, M. A. (2023). Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design. Drug Design, Development and Therapy, 17, 3661–3684. https://doi.org/10.2147/DDDT.S432790

Readers' Seniority

Tooltip

Lecturer / Post doc 2

50%

PhD / Post grad / Masters / Doc 1

25%

Researcher 1

25%

Readers' Discipline

Tooltip

Pharmacology, Toxicology and Pharmaceut... 2

33%

Engineering 2

33%

Agricultural and Biological Sciences 1

17%

Mathematics 1

17%

Save time finding and organizing research with Mendeley

Sign up for free