The plasma membrane as a control center for autophagy

34Citations
Citations of this article
55Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Autophagosomes may derive membrane from diverse sources, including the plasma membrane, Golgi, endoplasmic reticulum and mitochondria. The plasma membrane contributes membrane to ATG12-ATG5-ATG16L1- positive phagophore precursor vesicles (LC3-negative) by both clathrin-dependent and -independent routes. We recently observed that ARF6 regulates autophagy and that this could be explained, at least in part, by its role in the generation of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2], which influences endocytic uptake of plasma membrane into autophagosome precursors. The subsequent maturation of these small phagophore precursors into phagophores (ATG12-ATG5-ATG16L1-positive and LC3-positive), is assisted by SNAREmediated homotypic fusion that increase their size and enhance their ability to acquire LC3-II. It appears that a plasma membrane-derived pool of VAMP7 is a key mediator of these fusion events. Thus, events at the plasma membrane may regulate distinct steps in the biogenesis of phagophores. © 2012 Landes Bioscience.

Cite

CITATION STYLE

APA

Moreau, K., & Rubinsztein, D. C. (2012). The plasma membrane as a control center for autophagy. Autophagy. Taylor and Francis Inc. https://doi.org/10.4161/auto.20060

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free