Formal synthesis of (+)-lactacystin from l-serine

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Abstract

A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.

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Bulman Page, P. C., Goodyear, R. L., Chan, Y., Slawin, A. M. Z., & Allin, S. M. (2019). Formal synthesis of (+)-lactacystin from l-serine. RSC Advances, 9(51), 30019–30032. https://doi.org/10.1039/c9ra07244f

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