Cells must sense environmental conditions and adjust to maintain metabolic homeostasis and survive stress conditions; in this issue, Cam et al. (2010) show that the tumor suppressor kinase ATM is activated by hypoxia, phosphorylates and stabilizes HIF-1α, and inhibits mTORC1. © 2010 Elsevier Inc.
Kim, S. G., Choo, A. Y., & Blenis, J. (2010, November 24). ATM: Promoter of metabolic “Cost” reduction and “savings” usage during hypoxia through mTORC1 regulation. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.11.013