Blood-borne angiogenic factors and sustained multiple implantation: A comparison of singleton and twin pregnancies

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This study aimed to compare longitudinal serum concentrations of angiogenic implantation factors between ongoing singleton and twin pregnancies after double-embryo transfer and to investigate whether these are involved in sustained double implantation. Sixteen patients with an ongoing singleton and nine patients with an ongoing twin pregnancy after double-embryo transfer were included in this prospective observational study. Main outcome measures were concentrations of vascular endothelial growth factor-A (VEGF-A), inhibin A, glycodelin A, insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II), insulinlike growth factor binding protein-1 (IGFBP-1) and insulin-like growth factor binding protein-3 (IGFBP-3) at baseline, during the IVF treatment and in early pregnancy. It appeared that VEGF-A concentrations prior to any treatment and at early implantation as well as body mass index (BMI) were higher in women who conceived a twin pregnancy (P = 0.04). Soon after implantation, inhibin A concentrations were higher in twin pregnancies (P = 0.02). Secretion profiles of glycodelin A and members of the IGF family did not differ between singleton and twin pregnancies. VEGF-A appears to play a role in sustained double implantation. Furthermore a high BMI is associated with ongoing double implantation. Future studies should investigate the predictive value of VEGF-A for having an ongoing singleton or twin pregnancy. © 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.




Groeneveld, E., Lambers, M. J., Hoozemans, D. A., Schats, R., Hompes, P. G. A., & Lambalk, C. B. (2010). Blood-borne angiogenic factors and sustained multiple implantation: A comparison of singleton and twin pregnancies. Reproductive BioMedicine Online, 20(6), 822–830.

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