ASSOCIATION OF HEART FAILURE RISK FACTORS WITH LEFT VENTRICLE LONGITUDINAL CHANGE IN HISPANICS: THE ECHOCARDIOGRAPHIC STUDY OF LATINOS (ECHO-SOL)

Abstract

Background Hispanics have a high burden of heart failure (HF) risk factors (RFs) and subclinical left ventricular (LV) dysfunction. The change in HF RFs and its association with longitudinal change in LV echo parameters among Hispanics has not been evaluated. Methods Participants with echo at baseline and ~4.5 years follow-up exam from the Echo-SOL study were included. Change for each LV echo parameter was analyzed: LV mass index (LVMI), LV ejection fraction (LVEF), relative wall thickness (RWT), E/e’ ratio, e’ and global longitudinal strain (GLS). Change in HF RFs was also evaluated: systolic blood pressure (SBP), diastolic blood pressure (DBP), hemoglobin A1C (HbA1c), body mass index (BMI). The association between baseline HF RFs and change in LV echo parameters over time was evaluated using adjusted linear regression models for age, gender and time between scans with complex survey procedures. Results Among 1,643 participants (mean age 56 years, 45% male), all LV echo parameters worsened (p < 0.01 for all). SBP and HbA1c increased but DBP and BMI decreased during follow-up (p < 0.01 for all). Higher baseline HbA1c was associated with an increase in E/e’ (β=0.32, p<0.01), and higher baseline SBP was associated with decrease in e’ over time (β=0.01, p=0.03). Conclusion Hispanics exhibit worsening LV remodeling and function over time, in which HbA1c and SBP were positively correlated with worsening LV diastolic function. These observed changes highlight the risk for incident HF in this population. [Formula presented]