EFFECT OF 5‐HYDROXYTRYPTAMINE ON THE RESPIRATION OF EXCISED LAMELLIBRANCH GILL

Abstract

5‐Hydroxytryptamine, but not acetylcholine or catecholamines, stimulated the endogenous respiration of the excised gills of Modiolus demissus and Mytilus edulis. Respiratory stimulation by 5‐hydroxytryptophan is presumed to have occurred only after it had been decarboxylated to 5‐hydroxytryptamine. 2‐Bromolysergic acid diethyl‐amide inhibited the effect of 5‐hydroxytryptamine, while lysergic acid diethylamide mimicked it. The glycogen that was degraded during incubation of the gill cannot account for all of the oxygen that was consumed, indicating that some other substrate within the gill was also oxidized. That the metabolic actions of 5‐hydroxytryptamine may be related to its cilio‐acceleratory activity is discussed. 1961 British Pharmacological Society