Catabolism of Phenylacetic Acid in Escherichia coli

Abstract

Experimental studies of Alzheimer’s disease have largely\rdepended on transgenic mice overexpressing amyloid precursor\rprotein (APP). These mice, however, suffer from artificial\rphenotypes because, in addition to amyloid b peptide (Ab),\rthey overproduce other APP fragments. We generated knock-in\rmice that harbor Swedish and Beyreuther/Iberian mutations\rwith and without the Arctic mutation in the APP gene.\rThe mice showed typical Ab pathology, neuroinflammation\rand memory impairment in an age-dependent manner.