Aspartate aminotransferase-To-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis-coinfected men

Abstract

The utility of longitudinal AST-To-platelet ratio index (APRI), a surrogate for hepatic fibrosis, is unknown.We compared APRI up to 9 years before liver-related death among 57 cases of viral hepatitis-infected men (91% HIVR) to matched controls. APRI was stable among controls but, among cases, increased 4.6%/year from 9 to 3 years predeath (PU0.10) and 30%/year during the 3 years predeath (P0.001). Thus, rapid APRI increase may predict impending liver-related death in HIV-viral hepatitis coinfection.