Formulation and in vitro evaluation of transdermal matrix patches of doxofylline

Abstract

In this, slog efforts were made to fabricate and assess transdermal matrix patches of doxofylline for controlled drug delivery. Matrix type transdermal patch of doxofylline was fabricated by employing distinct proportions of hydroxy propyl methyl cellulose E-50 (HPMC E-50) and poly vinyl pyrrolidone as polymers by solvent evaporation technique. HPMC cellulose ester deemed as controlled-release agent in hydrophilic matrix systems as their gelforming ability. Dimethyl sulfoxide (DMSO) 12% of polymer weight and polyethylene glycol 400 36% of polymer weights were utilized as penetration enhancer and plasticizer, respectively. The physicochemical compatibility of the drug and the polymers studied by differential scanning calorimetry and attenuated total reflection demonstrated the absence/non-appearance of any incompatibility. All the prepared patches were physically assessed for their appearance, thickness, weight variation, and percentage moisture loss, percentage moisture absorption, folding endurance, flatness, and drug content. In vitro drug release studies were carried using Franz diffusion cell. All prepared formulations indicated good physical stability. Formulation prepared with HPMC E-50 lone exhibited foremost in vitro release via dialysis membrane as compared to all other formulations.