Risk factors for Alzheimer's disease: A population-based, longitudinal study in Manitoba, Canada

Abstract

Background: Current knowledge of risk factors for Alzheimer's disease (AD) is limited. Data from a longitudinal, population-based study of dementia in Manitoba, Canada were used to investigate risk factors for AD. Methods: Cognitively intact subjects completed a risk factor questionnaire assessing sociodemographic, genetic, environmental, medical and lifestyle exposures. Five years later, 36 subjects had developed AD and 658 remained cognitively intact. Results: Older subjects or those who had fewer years of education were at greater risk of AD. After adjusting for age, education and sex, occupational exposure to fumigants/defoliants was a significant risk factor for AD (relative risk [RR] = 4.35; 95% CI : 1.05-17.90). A history of migraines increased the risk of AD (RR = 3.49; 95% CI : 1.39-8.77); an even stronger effect was noted among women. Self-reported memory loss at baseline was associated with subsequent development of AD (RR = 5.15; 95% CI : 2.36-11.27). Vaccinations and occupational exposure to excessive noise reduced the risk of AD. Conclusions: Some well-known risk factors for AD were confirmed in this study and potential new risk factors were identified. The association of AD with a history of migraines and occupational exposure to defoliants/fumigants is of particular interest because these are biologically plausible risk factors.