Hepatoprotective and antioxidant activity of ethanol extracts of Dipterocarpus turbinatus (Dipterocarpaceae) from Tripura

Abstract

Ethanol extracts from the bark of Dipterocarpus turbinatus (EEDT) was evaluated for its hepatoprotective activity by paracetamol and carbon tetrachloride induced hepatotoxicity in rats. Hepatotoxicity was done by using carbon tetra chloride (2ml/kg) and paracetamol (3gm/kg) in rats. 200mg/kg and 400mg/kg of ethanol extracts of D. turbinatus (EEDT) was used as test drugs while silymarin (50mg/kg) used as a standard. Blood was collected by retro orbital pluxes and various biochemical parameters were evaluated related to liver disorder. Various parameters like SGOT, SGPT, ALP, cholesterol, serum bilirubin and levels significantly decreased with the dose dependence manner for EEDT as compared to paracetamol and CCl4 induced hepatotoxicity in rats. Total protein level was significantly increasing to test drug treated group as compared to the toxic control. Anti oxidant potency of drug was determined by various in-vitro methods and the drug extracts have shown positive results. Therefore, we conclude that it can be used for the treatment of hepatic damage where anti oxidant property is supported for its hepatoprotective activity.