Persistent thrombocytosis in β-thalassemia post-splenectomy: A STROBE-compliant retrospective cohort study at a Jordanian referral center

Abstract

Beta-thalassemia is a prevalent autosomal recessive hematological disorder characterized by defective β-globin chain production. Splenectomy is commonly performed in severe cases to alleviate transfusion dependency, but persistent post-splenectomy thrombocytosis poses significant clinical challenges. This Strengthening the Reporting of Observational Studies in Epidemiology-compliant retrospective cohort study included β-thalassemia major patients who underwent splenectomy at Al-Bashir Hospital between 2018 and 2024. Hematologic and biochemical parameters before and 1 year after surgery were compared using paired t tests after verifying data normality with the Shapiro–Wilk test (P > .05). A P value