The self-non-self theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the "danger theory." This theory has provoked mixed acclaim: enthusiasm and criticism. Here we assess the danger theory vis-à-vis recent experimental data on innate immunity, transplantation, cancers and tolerance to foreign entities, and try to elucidate more clearly whether danger is well defined. © 2012 Pradeu and Cooper.
Pradeu, T., & Cooper, E. L. (2012). The danger theory: 20 years later. Frontiers in Immunology, 3(SEP). https://doi.org/10.3389/fimmu.2012.00287