Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease

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Abstract

Study Objective: A preliminary study by our group suggested an association between daytime sleepiness and the catechol-O-methyltransferase (COMT) val 158met polymorphism (rs4680) in patients with Parkinson disease (PD). We sought to confirm this association in a large group of patients with PD. Design: Genetic association study in patients with PD. Setting: Movement disorder sections at 2 university hospitals. Participants: PD patients with and without episodes of suddenly falling asleep matched for antiparkinsonian medication, disease duration, sex, and age, who participated in a previous genetic study on dopamine-receptor polymorphisms. Interventions: Not applicable. Measurements and Results: In this study, 240 patients with PD (154 men; age 65.1 ± 6.1 years; disease duration 9.4 ± 6.0 years) were included. Seventy had the met-met (LL), 116 the met-val (LH), and 54 the val-val (HH) genotype. In the combined LL+LH group (featuring reduced COMT activity), the mean Epworth Sleepiness Scale (ESS) score was 9.0 ± 5.9 versus 11.0 ± 6.1 in the HH (high COMT activity) group (P = .047). Forty-seven percent of the LL and LH patients had sudden sleep onset compared with 61% of the HH patients (P = .07). Logistic regression, however, showed that both pathologic ESS scores (i.e., > 10) and sudden sleep onset were predicted by subjective disease severity (P < .001 each) but not by the COMT genotype. Conclusions: Our previous finding that the L-allele may be associated with daytime sleepiness could not be confirmed in the present study. Altogether, our data do not support a clinically relevant effect of the COMT genotype on daytime sleepiness in PD.

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Rissling, I., Frauscher, B., Kronenberg, F., Tafti, M., Stiasny-Kolster, K., Robyr, A. C., … Möller, J. C. (2006). Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease. Sleep, 29(1), 108–111. https://doi.org/10.1093/sleep/29.1.108

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