Nephroprotective activity of ethanol extract root of cogon grass (Imperata Cylindrica L. (Beauv.)) on creatinine, urea levels, and hematology profile against gentamycin-induced renal toxicity in rats

Abstract

Objective: This study aimed to evaluate the effect of ethanol extract root of cogon grass on parameter creatinine, urea levels, and hematology profile in rats induced by gentamicin. Methods: Thirty rats were divided into 6 groups of normal group (without treatment), groups of treatment only fed and watered, given carboxymethylcellulose (CMC) 0.5%, ethanol extract of the roots of cogon grass with each dose of 100, 200, and 400 mg/kg BW. Each group was given the test preparation orally for 8 days. After 1 h, 5 groups were induced by gentamicin at a dose 100 mg/kg bw intraperitoneally during 8 days. On the 9th day, blood samples were collected for serum creatinine, urea levels, and hematological parameters; hemoglobin (Hb), red blood cell, and packed cell volume. Results: Ethanol extract root of cogon grass doses of 100 mg/kg bw, 200 mg/kg bw, and 400 mg/kg BW significantly decreased serum creatinine and urea levels, significantly increased hematological parameters as compared to negative control group of CMC 0.5% and negative control group not given CMC 0.5% (p<0.05). Ethanol extract root of cogon grass at a dose of 400 mg/kg bw showed there were not differences of creatinine, urea levels, and profile of hematology compared with normal group (p>0.05). Conclusion: The ethanol extract root of cogon grass at a dose of 400 mg/kg bw was effective to ameliorate creatinine, urea levels, and hematological parameters.