Design and characterization of membrane molecularly imprinted polymer (MIP) as cholesterol absorbent

Abstract

Molecularly Imprinted Polymer (MIP) membrane as cholesterol absorbing have succesfull synthesized. MIP membrane can absorb cholesterol molecules because have cavite (pore) and active groups that are selective and sensitive to cholesterol molecules. MIP membranes synthesized from methacrylic acid monomer, cross-linker ethylene glycol dimethacrilate (EGDMA), initiator of the 2-2-dimethoxy-2-phenylacetophenone (DMPP) and cholesterol as a template. MIP membranes are synthesized using photopolynerization irradiated with UV light (UV). Results obtained in the form of leaflets and transparent membrane can be characterized using Fourier Transform Infrared (FTIR). The results obtained by FTIR spectrum showed that the characterization of infrared spectra of MIP membrane-extraction did not reveal any peak absorption by the OH group, whereas MIP-Re-extraction contained absorption peaks in the area of 3540.58 cm-1. This indicates that the MIP membrane selective and sensitive to analyte. Based on the optimum absorption of MIP-cholesterol membrane can absorb the cholesterol molecules in the amount of 0.06 grams of cholesterol composition with a time of 30 minutes and a pH of 8. The average cholesterol absorption MIP membranes-cholesterol in the blood 0.5782mg/dL.