Hypoglycemic effect by assay some glucoregulatory enzymes and hematological parameters using silver nanoparticles of peel Raphanus sativus L aqueas extract in male Rats.

Abstract

Hypoglycemic effect was investigated some glucoregulatory enzymes ( Serum insulin level, superoxide dismutase (SOD), catalase activity ) and hematological parameters in male rats divided into five groups six rats for each group: G1: control group (treated with normal saline), G2: diabetic groups induced by alloxan in a single dose (150 mg/kg b.w ), G3: Diabetic groups (alloxan 150 mg/kg b.w intraperitoneal injection for 60 days + 100ppm of Nanoparticles extract)G4: preventive group(intraperitoneal injection for 60 days of 100ppm of Nanoparticles + alloxan in a single dose (150mg/kg b.w), G5: (Control treated with 100 ppm of nanoparticles for 60 days). The results shown a significant increase in insulin level, red blood cells and hemoglobin content at (p<0.05) for the treated group(G3) and the preventive group(G4) when it was compared with diabetic group while decreased in the levels at (p<0.05) of catalase activity and white blood cells for the treated group(G3) and the preventive group(G4) when compared with diabetic group.