Synthesis of the diketopiperazine dipodazine

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Abstract

The diketopiperazine derivative dipodazine (1), isolated from Penicillium dipodomyis, has been synthesized via a stereoselective aldol condensation from N-protected indole-3-carboxaldehyde and 1,4-diacetyl-2,5-piperazinedione (3) in the presence of cesium carbonate.

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Johnson, A. L., Janosik, T., & Bergman, J. (2002). Synthesis of the diketopiperazine dipodazine. Arkivoc, 2002(8), 57–61. https://doi.org/10.3998/ark.5550190.0003.807

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