Epidermal barriers

55Citations
Citations of this article
89Readers
Mendeley users who have this article in their library.

Abstract

The epidermis functions as a physical barrier to the external environment and works to prevent loss of water from the skin. Numerous factors have been implicated in the formation of epidermal barriers, such as cornified envelopes, corneocytes, lipids, junctional proteins, proteases, protease inhibitors, antimicrobial peptides, and transcription factors. This review illustrates human diseases (ichthyoses) and animal models in which the epidermal barrier is disrupted or dysfunctional at steady state owing to ablation of one or more of the above factors. These diseases and animal models help us to understand the complicated mechanisms of epidermal barrier formation and give further insights on epidermal development. © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.

Cite

CITATION STYLE

APA

Natsuga, K. (2014). Epidermal barriers. Cold Spring Harbor Perspectives in Medicine. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/cshperspect.a018218

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free