Asymmetric hydroarylation of hetero-atom containing norbornene derivatives and enantioselective synthesis of analogs of epibatidine

Abstract

The reductive Heck-type hydroarylation reactions of hetero-atom containing norbornene derivatives catalyzed by palladium complexes of chiral quinolinyl-oxazolines were examined and moderate to good chiral inductions and chemical yields were achieved. Using this new method N-protected epibatidine was readily synthesized.