Regulation of the G2/M transition in rodent oocytes

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Abstract

Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell-cell coupling pathways. This review highlights recent advances in our understanding of how such signaling controls both meiotic arrest and gonadotropin-triggered meiotic resumption in competent oocytes and relates them to the historical context. Emphasis will be on rodent systems, where many of these new findings have taken place. A regulatory scheme is then proposed that integrates this information into an overall framework for meiotic regulation that demonstrates the complex interplay between different follicular compartments. © 2010 Wiley-Liss, Inc.

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APA

Downs, S. M. (2010, July). Regulation of the G2/M transition in rodent oocytes. Molecular Reproduction and Development. https://doi.org/10.1002/mrd.21175

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