Posterior reversible encephalopathy syndrome presenting atypically as a non-convulsive seizure

Abstract

Objective: Background: Case Report: Conclusions: Unusual clinical course Posterior reversible encephalopathy syndrome (PRES), also known as reversible posterior leukoencephalopa-thy, is a neurotoxic state with multiple etiologies characterized by altered mental state, headaches, visual ab-normalities, and seizures. This clinico-radiological syndrome is rare, and a high index of suspicion is needed to diagnose, provide adequate treatment, and prevent irreversible neurological sequelae. We present a case of a woman with end-stage renal disease (ESRD) who presented with acute confusion and non-convulsive seizures and was later diagnosed with PRES. In this case, altered mental status was initially thought to be secondary to uremic encephalopathy. A diagnosis of PRES was subsequently made after she had several sessions of HD without significant improvement in her mental state, prompting magnetic resonant imaging (MRI) for further evaluation. Specific risk factors for PRES, including blood pressure fluctuations, were targeted and she made significant clinical recovery but had residual functional impairment. This case underscores the need for a high index of suspicion, especially in cases with atypical presentation, as delayed diagnosis can lead to suboptimal outcomes.