T lymphocyte chemotaxis and skin diseases

Abstract

Abstract Recent advances in our understanding of the mechanisms of T lymphocyte motility and chemotaxis, particularly in aspects of lymphocyte‐endothelial adhesion, transendothelial cell migration, and T‐lymphocyte response to chemotactic gradients have contributed to our knowledge of how T lymphocytes accumulate during the initiation, the development and the control of inflammatory skin responses. In this review, we will summarize the present situation of studies on T lymphocyte adhesion and chemotaxis. The 3 major steps in T lymphocyte chemotaxis, e.g., recognition of extracellular chemotactic gradients, transduction into ap‐propriate intracellular signals, and generation of motion, will be out‐lined. Skin‐homing T lymphocytes, chemokines and other chemoattractants will also be discussed in relation to skin diseases. Copyright © 1995, Wiley Blackwell. All rights reserved