Activation of red cell Ca2+ -activated K+ channel by Ca2+ involves a temperature-dependent step

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Abstract

We found that vanadate-induced 45Ca2+ uptake by red cells is maximal at 25°C. At this temperature, the Cai-induced increase of the K+ permeability (the Gardos effect) shows a lag (up to 8 min) which is not observed at 37°C. This cannot be explained by the lack of availability of Ca2+ for the Ca2+-activated K+ channel, and suggests that its activation by Ca2+ is mediated by a temperature-dependent mechanism which remains unknown so far. The lag is not observed when the Gárdos effect was initiated by propranolol. This shows that the putative temperature-dependent step is different from chloride transport. © 1990.

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Varečka, Ĺ., & Peterajová, E. (1990). Activation of red cell Ca2+ -activated K+ channel by Ca2+ involves a temperature-dependent step. FEBS Letters, 276(1–2), 169–171. https://doi.org/10.1016/0014-5793(90)80534-P

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