Biotransformation processes have been successfully utilized to obtain products of pharmaceutical, chemical, food, and agricultural interest, which are difficult to obtain by classic chemical methods. The compound with antituberculous activity, 9-methoxy-tariacuripyrone (1), isolated from Aristolochia brevipes, was submitted to biotransformation with the yeast Saccharomyces cerevisiae under culture, yielding 5-amino-9-methoxy-3, 4-dihydro-2H-benzo[h]chromen-2-one (2). The structure of 2 was elucidated on the basis of spectroscopic analyses. The results mainly show the reduction of the double bond and the nitro group of compound 1. Metabolite 2 demonstrated an increase in anti-tuberculous activity (MIC = 3.12 μg/mL) against the drug-sensitive Mycobacterium tuberculosis (H37Rv) strain, with respect to that shown by 1. © 2012 by the authors.
Alvarez-Fitz, P., Alvarez, L., Marquina, S., Luna-Herrera, J., & Navarro-García, V. M. (2012). Enzymatic reduction of 9-methoxytariacuripyrone by saccharomyces cerevisiae and its antimycobacterial activity. Molecules, 17(7), 8464–8470. https://doi.org/10.3390/molecules17078464