Effects of dexamethasone on human natural killer cell cytotoxicity, interferon production, and interleukin-2 receptor expression induced by microbial antigens

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Abstract

Dexamethasone inhibits the expression of the interleukin-2 receptor, the synthesis of immune interferon, and the development of natural killer cells when added to peripheral blood mononuclear cells cultured with soluble microbial antigens (purified protein derivative and a polysaccharide extract from Candida albicans [MPPS]) or human recombinant interleukin-2.

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Piccolella, E., Lombardi, G., Vismara, D., Gallo, F. D., Colizzi, V., Dolei, A., & Dianzani, F. (1986). Effects of dexamethasone on human natural killer cell cytotoxicity, interferon production, and interleukin-2 receptor expression induced by microbial antigens. Infection and Immunity, 51(2), 712–714. https://doi.org/10.1128/iai.51.2.712-714.1986

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