Peripheral myelin protein-22 is expressed in CNS myelIn

Abstract

Myelin abnormalities exist in schizophrenia leading to the hypothesis that oligodendrocyte dysfunction plays a role in the pa thophysiology of the disease . The expression of the mRNA f or the peripheral myelin protein-22 (PMP-22) is decreased in schizophrenia and recent genetic evidence suggests a link bet ween PMP-22 and schizophrenia. While PMP-22 mRNA is f ound in both r odent and human br ain it has been generally thought that no protein expression occurs. Here we show that PMP-22 protein is present in myelin isolated from adult mouse and human br ain. These results suggest that PMP-22 protein likely plays a role in the main tenance and func tion of central nervous system (CNS) myelin and provide an explanation for why altered PMP-22 expression may be pathophysiologically relevant in a CNS disor der such as schizophrenia © Versita Sp. z o.o.