Synthesis hydroxyapatite/collagen/chitosan composite for tissue engineering

Abstract

Hydroxyapatie/Collagen/Chitosan composite has been synthesized by ex-situ methods. The purpose of this research is to study the composition's effect of the composite HA/Coll/Chi to some characters such as a functional group and phase as well as the physical character such as crystallinity, the compressive strength and surface morphology. HA synthesized from the precursor calcium derived from duck eggshell reacted with H3PO4, HA sintered at 900 °C. HA was added with collagen and chitosan solutin with a mass ratio of the composition HA/Coll/Chi are 7: 2: 1; 7: 1,5: 1,5; 7: 1: 2. FTIR analysis showed a band PO43-and OH- adsorption of HA, as well as a shift vibration of spectra in the group C = O and NH2 from chitosan and collagen that shows there has been a bond between collagen, chitosan and HA. Data of XRD showed that the phase of HA and chitosan in the composite of HA/Coll/Chi. Composite with collagen component hight has low cristalinity.