The relationship between calcium current and transmitter release was studied in squid giant synapse. It was found that the voltage-dependent calcium current triggers the release of synaptic transmitter in direct proportion to its magnitude and duration. Transmitter release occurs with a delay of approximately 200 mus after the influx of calcium. A model is presented which describes these relations formally. © 1981, The Biophysical Society. All rights reserved.
Llinás, R., Steinberg, I. Z., & Walton, K. (1981). Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse. Biophysical Journal, 33(3), 323–351. https://doi.org/10.1016/S0006-3495(81)84899-0