Consensus Statement on Neurofilament Proteins in Multiple Sclerosis Under Development by Consortium of Multiple Sclerosis Centers (CMSC) Expert Panel

Abstract

Neurofilaments are intracellular cytoskeletal proteins that leak into cerebrospinal fluid (CSF) and blood as a result of neuronal damage. 1 Blood and CSF neurofilament levels are elevated in a number of neurologic diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis, and Parkinson disease, as well as in traumatic brain injury.2,3 In MS, change in serum or CSF neurofilament levels is emerging as an important biomarker to detect disease progression and response to treatment.4 Such blood and CSF biomarkers are significantly lacking and much needed in MS care and research.