Journal ArticleOPEN ACCESS

Cobalt hematoporphyrin inhibits CLEC-2–podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice

  • Tsukiji N
  • Osada M
  • Sasaki T
  • et al.
Blood Advances (2018) 2(17) 2214-2225
DOI: 10.1182/bloodadvances.2018016261
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Abstract

Co-HP binds to CLEC-2 at N120 and K211, novel binding sites for podoplanin, and inhibits their interaction. Co-HP prevents hematogenous tumor metastasis and arterial/venous thrombosis in mice, without a significant increase in bleeding time.

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Tsukiji, N., Osada, M., Sasaki, T., Shirai, T., Satoh, K., Inoue, O., … Suzuki-Inoue, K. (2018). Cobalt hematoporphyrin inhibits CLEC-2–podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice. Blood Advances, 2(17), 2214–2225. https://doi.org/10.1182/bloodadvances.2018016261

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