Abstract
The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
Cite
CITATION STYLE
APA
Coverdale, J. P. C., van den Berg, H. A., Khazaipoul, S., Bridgewater, H. E., Stewart, A. J., & Blindauer, C. A. (2022). Albumin-mediated extracellular zinc speciation drives cellular zinc uptake. Chemical Communications, 58(53), 7384–7387. https://doi.org/10.1039/d2cc02278h
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