Studies on the Metabolic Products of Aspergillus terreus. II.1) Structure and Biosynthesis of the Metabolites of the Strain ATCC 12238

Abstract

New compounds, 6-hydroxytoluquinol-hydrate (3,4) (VI), terremutin-hydrate (VII), and 4-chloro-3,6-dihydroxytoluquinone (II) were isolated from Aspergillus terreus ATCC 12238 together with terreic acid, terremutin, 3,6-dihydroxytoluquinone, and terrein. The metabolic relationships among the metabolites were studied by administration experiments using 14C-compounds and the metabolic scheme was proposed. The metabolic pattern of “epoxy compounds (terreic acid and terremutin)→quinone (3,6-dihydroxytoluquinone) or its quinol→hydroaromatic compound (VI)” was essentially the same as observed in Aspergillus fumigatus DH 413 and IFO 4399. © 1977, The Pharmaceutical Society of Japan. All rights reserved.