Potential use of Piper nigrum ethanol extract against pyrethroid-resistant Aedes aegypti larvae

Abstract

Fractionation of Piper nigrum ethanol extract, biomonitored by assays on pyrethroid-resistant Aedes aegypti larvae yielded isolation of the larvicidal amides piperolein-A and piperine. Comparing LC50 values, the ethanol extract (0.98 ppm) was the most toxic, followed by piperolein-A (1.46ppm) and piperine (1.53ppm).