Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings taxonomy, production and enzyme inhibition

Abstract

Adecypenol, which exhibits potent inhibitory activity against calf intestinal adenosine deaminase (EC 3.5.4.4), was isolated from the cultured broth of Streptomyces sp. OM-3223. Adecypenol was classified as a semi-tight binding inhibitor. The Ki value against calf intestinal adenosine deaminase was 4.7X10-9M.No acute toxicity of adecypenol was observed at 100 mg/kg in mice. Adecypenol exhibited no antimicrobial activity against various bacteria and fungi at the concentration of 1.0 mg/ml. © 1986, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.