Skip to content

SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population

9Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Background: Bipolar disorder (BPD) is a common, severe and recurrent psychiatric disorder. It has been suggested that BPD patients have a higher risk of suicide than patients with any other psychiatric illnesses. A recent study found that suicide attempt was associated with the SCN8A gene, which has been mapped close to one of the BPD susceptibility loci. Thus, SCN8A is likely to be a candidate gene for BPD. Methods: In this study, three SNPs (rs1601012, rs303810, rs60637) were analyzed in 506 bipolar patients and 507 controls of Han origin. Results: We found that two individual SNPs showed statistically significant differences between cases and controls in both allele and genotype distribution, but only rs303810 was still significant in allele distribution (p = 0.0164) after correction. No obvious linkage disequilibrium or haplotypes were observed among these SNPs. Conclusion: Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population. © 2008 Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Wang, Y., Zhang, J., Li, X., Ji, J., Yang, F., Wan, C., … He, G. (2008). SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(8), 1902–1904. https://doi.org/10.1016/j.pnpbp.2008.09.003

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free