Background: Bipolar disorder (BPD) is a common, severe and recurrent psychiatric disorder. It has been suggested that BPD patients have a higher risk of suicide than patients with any other psychiatric illnesses. A recent study found that suicide attempt was associated with the SCN8A gene, which has been mapped close to one of the BPD susceptibility loci. Thus, SCN8A is likely to be a candidate gene for BPD. Methods: In this study, three SNPs (rs1601012, rs303810, rs60637) were analyzed in 506 bipolar patients and 507 controls of Han origin. Results: We found that two individual SNPs showed statistically significant differences between cases and controls in both allele and genotype distribution, but only rs303810 was still significant in allele distribution (p = 0.0164) after correction. No obvious linkage disequilibrium or haplotypes were observed among these SNPs. Conclusion: Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population. © 2008 Elsevier Inc. All rights reserved.
Wang, Y., Zhang, J., Li, X., Ji, J., Yang, F., Wan, C., … He, G. (2008). SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(8), 1902–1904. https://doi.org/10.1016/j.pnpbp.2008.09.003