Abstract
A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents. © 2010 by the authors; licensee MDPI, Basel, Switzerland.
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Zhu, Y., Zhang, Y., Liu, Y., Chu, H., & Duan, H. (2010). Synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents. Molecules, 15(12), 9174–9183. https://doi.org/10.3390/molecules15129174
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