Aggressive natural killer-like T-cell malignancy with leukemic presentation following solid organ transplantation

24Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

NK-like T-cell malignancies are part of a spectrum of lymphoproliferative diseases that complicate immunosuppression associated with solid organ transplantation. We describe 2 patients with longstanding immunosuppression following solid organ transplantation. Both patients had systemic symptoms that included fever, myalgia, and weight loss. Organ involvement and lymphadenopathy were not initially observed. Unique to these 2 cases are the initial leukemic symptoms, which led to further characterization and identification of NK-like T-cell malignancies. Both patients exhibited an anomalous T/NK phenotype, CD56 positivity, and atypical blastic architecture of the large granular lymphocytes. Clonal rearrangement of T-cell receptor genes was detected in both patients. In 1 patient, a cytogenetic abnormality involving 8q24 was demonstrated the disease course in both patients was aggressive, with involvement of multiple sites and rapid demise. This study emphasizes the importance of including NK-like T-cell malignancies in the differential diagnosis of lymphoproliferative disorders associated with immunosuppression and recognizing that an aggressive clinical course may follow leukemic presentation of disease.

Cite

CITATION STYLE

APA

Natkunam, Y., Warnke, R. A., Zehnder, J. L., & Combleet, P. J. (1999). Aggressive natural killer-like T-cell malignancy with leukemic presentation following solid organ transplantation. American Journal of Clinical Pathology, 111(5), 663–671. https://doi.org/10.1093/ajcp/111.5.663

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free