The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2

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Abstract

Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2. © 2007 Federation of European Biochemical Societies.

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Lolkema, M. P., Mans, D. A., Snijckers, C. M., van Noort, M., van Beest, M., Voest, E. E., & Giles, R. H. (2007). The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Letters, 581(24), 4571–4576. https://doi.org/10.1016/j.febslet.2007.08.050

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