Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis

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Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; dioxin), a member of a class of environmental pollutants represented by polychlorinated dibenzo-p-dioxins and dibenzofurans, is one of the most toxic artificial compounds ever developed. In this study, we identified a novel TCDD target gene, DIF-3 (dioxin inducible factor-3), by cDNA representational difference analysis. DIF-3 protein is a nuclear factor and possesses a zinc-finger motif at its N-terminus. High DIF-3 mRNA expression in the testes was demonstrated by Northern blot analysis and abundant DIF-3 protein was detected during spermatogenesis. Thus, these results suggest that DIF-3 may be a target gene mediating the reproductive toxicity induced by TCDD. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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Ohbayashi, T., Oikawa, K., Iwata, R., Kameta, A., Evine, K., Isobe, T., … Mukai, K. (2001). Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. FEBS Letters, 508(3), 341–344. https://doi.org/10.1016/S0014-5793(01)03039-3

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