Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis

Citations of this article
Mendeley users who have this article in their library.


2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; dioxin), a member of a class of environmental pollutants represented by polychlorinated dibenzo-p-dioxins and dibenzofurans, is one of the most toxic artificial compounds ever developed. In this study, we identified a novel TCDD target gene, DIF-3 (dioxin inducible factor-3), by cDNA representational difference analysis. DIF-3 protein is a nuclear factor and possesses a zinc-finger motif at its N-terminus. High DIF-3 mRNA expression in the testes was demonstrated by Northern blot analysis and abundant DIF-3 protein was detected during spermatogenesis. Thus, these results suggest that DIF-3 may be a target gene mediating the reproductive toxicity induced by TCDD. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.




Ohbayashi, T., Oikawa, K., Iwata, R., Kameta, A., Evine, K., Isobe, T., … Mukai, K. (2001). Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. FEBS Letters, 508(3), 341–344. https://doi.org/10.1016/S0014-5793(01)03039-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free