Monitoring of biochemical effects of organochlorine pesticides on human health

Abstract

The present study was\rdesigned to analyze organochlorine pesticide residues in the blood samples of\rthe residents of Karachi. Biochemical and hematological parameters were\rtested thoroughly for changes as a result of organochlorine residues. In the\rblood samples which were drawn from both genders, organochlorine compounds like α-endosulfan (1.565 mg/kg) and β-endosulfan (1.233 mg/kg) were found in\rhigher quantities and were the most frequently detected compounds. Average\rconcentrations of the detected compounds (mg/kg) were: HCH (0.819); Cyclodienes\r(2.839); Diphenylaliphatics (0.240). An evident finding was the alteration in\renzyme activity in higher residue samples. Levels of GPT, GOT, ALP, Choline-esterase\rand γ-GT were tested in all samples\rand observed major shifts in the upper and lower limits in high residue\rsamples as compared with the normal values. Analysis of the blood parameters\rwere carried out thoroughly and checked the levels of TLC, RBC, Hb, Hct, MCV,\rMCH, MCHC, Platelets and differential\rleucocytes (Neutrophils, Lymphocytes, Eosinophils and Monocytes) but\rfound no distinct changes and hence no convincing relation was observed. Results\rof the present investigation of OCs in different blood sera indicated that\rbioconcentration and biomagnification of these chemicals were common phenomena\rin the population of Karachi city and this may be accountable for a variety of\rdiseases and health hazards.