Left ventricular failure with labetalol

Abstract

A patient treated for hypertension with labetalol developed left ventricular failure. When the drug was withdrawn and the BP controlled with 2 other agents, the signs of heart failure regressed. The ill effects in this case could have been because the (3-blocking effects of labetalol are 4 to 6 times greater than the a-blocking effects. Caution should be exercised when prescribing this drug for patients with heart failure or with previous symptoms. © 1979 The Fellowship of Postgraduate Medicine.